Journal article
Restrictive or liberal red-cell transfusion for cardiac surgery
CD Mazer, RP Whitlock, DA Fergusson, J Hall, E Belley-Cote, K Connolly, B Khanykin, AJ Gregory, E De Medicis, S McGuinness, A Royse, FM Carrier, PJ Young, JC Villar, HP Grocott, MD Seeberger, S Fremes, F Lellouche, S Syed, K Byrne Show all
New England Journal of Medicine | MASSACHUSETTS MEDICAL SOC | Published : 2017
Abstract
BACKGROUND The effect of a restrictive versus liberal red-cell transfusion strategy on clinical outcomes in patients undergoing cardiac surgery remains unclear. METHODS In this multicenter, open-label, noninferiority trial, we randomly assigned 5243 adults undergoing cardiac surgery who had a European System for Cardiac Operative Risk Evaluation (EuroSCORE) I of 6 or more (on a scale from 0 to 47, with higher scores indicating a higher risk of death after cardiac surgery) to a restrictive red-cell transfusion threshold (transfuse if hemoglobin level was <7.5 g per deciliter, starting from induction of anesthesia) or a liberal red-cell transfusion threshold (transfuse if hemoglobin level was ..
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Awarded by Canadian Institutes of Health Research
Funding Acknowledgements
Supported by grants (232416 and 301852) from the Canadian Institutes of Health Research, by a grant (Kenneth J. Fyke Award, to Dr. Shehata) from the Canadian Blood Services-Health Canada, by a grant (1085942) from the National Health and Medical Research Council of Australia, and by a grant (16/353) from the Health Research Council of New Zealand.